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I hail from Chandigarh which is also called as city beautiful in India. I did my M.S. at Panjab University, India. After securing a CSIR/UGC fellowship, I completed my Ph.D. at IMTECH Chandigarh in India. During my PhD studies, I investigated the structural, functional and kinetic details of mycobacterial polyphosphate kinase (PPK) 1, an enzyme required for mycobacteria survival under stress conditions and thus, could serve as a promising therapeutic target. I was always fascinated by the world of immunology and therefore, I joined the labs of Dr. Adam J. Adler and Dr. Anthony T. Vella at UConn for my postdoctoral studies. During my postdoc, I studied the mechanistic details on how dual costimulation (DCo) involving agonistic monoclonal antibodies against OX40 and 41BB provided tumor immunity. Additionally, I also explored the ways to further augment anti-tumor efficacy of DCO by engaging the tumor unrelated CD4 T cell help. Currently, I am working as a postdoctoral Scientist on a collaborative project between a pharma company GSK and Dr. Wayne Hancock’s lab at Children’s Hospital of Philadelphia. I am interested in studying the role of chemokine signaling in tumor immunity by utilizing small molecule based modalities.

Research

  • Histone/protein Deacetylases
    HDAC-e1502818213336
  • Histone/protein Acetyltransferases
  • Deubiquitinases
  • Transplantation
  • Tumor Immunology
  • Ischemia/reperfusion Injury
  • Immunometabolism

Hancock Lab

University of Pennsylvania School of Medicine
916B Abramson Research Center
3615 Civic Center Boulevard
Philadelphia, PA 19104
(215) 590-8709

Funding

National Institutes of Health (NIAID, NCI, NIDDK)
Department of Defense
Fred and Suzanne Biesecker Pediatric Liver Center

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