p300i promotes anti-tumor immunity in vivo (TC1)

Tumor Immunology

Our lab undertakes clinical and experimental oncology projects. The clinical work, headed by Dr. Tatiana Akimova, is undertaken in collaboration with Drs. Steve Albelda, Evgeniy Eruslanov and Sunil Singhal, and focuses on characterizing the features and functions of FOXP3+ Treg cells isolated from freshly resected human lung cancers. The murine work, headed by Dr. Liqing Wang, involves studies of the effects of targeting Foxp3+ Treg cells in murine lung cancer models in syngeneic mice.  The intent of our tumor studies is to understand how Tregs regulate host anti-tumor immunity, and ultimately how such actions can be modulated to therapeutic effect.

Tip60i impairs tumor growth in immunocompetent but not immunodeficient mice

Selected Publications

Ubiquitin-specific protease-7 inhibition impairs Tip60-dependent Foxp3+ T-regulatory cell function and promotes antitumor immunity. Wang L, Kumar S, Dahiya S, Wang F, Wu J, Newick K, Han R, Samanta A, Beier UH, Akimova T, Bhatti TR, Nicholson B, Kodrasov MP, Agarwal S, Sterner DE, Gu W, Weinstock J, Butt TR, AlbeldaSM, Hancock WW. EBioMedicine. 2016 Nov;13:99-112.
Free PMC Article

Origin and role of a subset of tumor-associated neutrophils with antigen-presenting cell features in early-stage human lung cancer. Singhal S, Bhojnagarwala PS, O’Brien S, Moon EK, Garfall AL, Rao AS, Quatromoni JG, Stephen TL, Litzky L, Deshpande C, Feldman MD, Hancock WW, Conejo-Garcia JR, Albelda SM, Eruslanov EB. Cancer Cell. 2016 Jul 11;30(1):120-35.
Free PMC Article

Tumor-associated neutrophils stimulate T cell responses in early-stage human lung cancer. Eruslanov EB, Bhojnagarwala PS, Quatromoni JG, Stephen TL, Ranganathan A, Deshpande C, Akimova T, Vachani A, Litzky L, Hancock WW, Conejo-Garcia JR, Feldman M, Albelda SM, Singhal S. J Clin Invest. 2014 Dec;124(12):5466-80.
Free PMC Article

An optimized disaggregation method for human lung tumors that preserves the phenotype and function of the immune cells. Quatromoni JG, Singhal S, Bhojnagarwala P, Hancock WW, Albelda SM, Eruslanov E. J Leukoc Biol. 2015 Jan;97(1):201-9.
Free PMC Article

Inhibition of p300 impairs Foxp3⁺ T regulatory cell function and promotes antitumor immunity. Liu Y, Wang L, Predina J, Han R, Beier UH, Wang LC, Kapoor V, Bhatti TR, Akimova T, Singhal S, Brindle PK, Cole PA, Albelda SM, Hancock WW. Nat Med. 2013 Sep;19(9):1173-7.
Free PMC Article