Currently, I am working with Dr. Wayne Hancock on post-translational modifications (PTM) of Foxp3 in regulatory T cells (Treg) and induced Treg (iTreg) cells. Our focus is to understand the molecular mechanisms by which PTM involving HATs (histone acetyl transferases), HDACs (histone deacetylases) and Kinases modulate master transcription factor Foxp3 stability and suppressive functions in Treg and iTreg cells. Foxp3 expression, stability and PTM play critical roles in regulation of autoimmunity and by suppressing alloreactive T cells, can promote transplant tolerance induction. We are also investigating the signaling pathways involved in iTreg cell generation, and co-operative interactions of transcription factors binding at conserved Foxp3 promoter enhancer regions.
Previously, I worked on HER2/NEU, EGF receptors tyrosine kinases, growth factors mediated activation, transcriptional signaling.
In addition to research, I love nature and enjoy gardening.
University of Pennsylvania School of Medicine
916B Abramson Research Center
3615 Civic Center Boulevard
Philadelphia, PA 19104