In studies extending interests in HDACs beyond Treg cells, Dr. Matt Levine and his group have set up models of renal, hepatic, limb and lung IRI and begun, using genetic and pharmacologic approaches, to identify the effects of HDAC targeting on outcomes of ischemia/reperfusion injury (IRI) different tissues. This ongoing work is showing major differences in the roles of HDACs in different tissues, and provides a clinically relevant system in which to elucidate the biochemical functions of large HDAC-containing multiprotein nuclear complexes that regulate gene expression in vivo.
Improved renal ischemia tolerance in females influences kidney transplantation outcomes. Aufhauser DD Jr, Wang Z, Murken DR, Bhatti TR, Wang Y, Ge G, Redfield RR 3rd, Abt PL, Wang L, Svoronos N, Thomasson A, Reese PP, Hancock WW, Levine MH. J Clin Invest. 2016 May 2;126(5):1968-77.
Class-specific histone/protein deacetylase inhibition protects against renal ischemia reperfusion injury and fibrosis formation. Levine MH, Wang Z, Bhatti TR, Wang Y, Aufhauser DD, McNeal S, Liu Y, Cheraghlou S, Han R, Wang L, Hancock WW. Am J Transplant. 2015 Apr;15(4):965-73.
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