Publications
2017
The Effects of Tacrolimus on T-Cell Proliferation Are Short-Lived: A Pilot Analysis of Immune Function Testing. Laskin BL, Jiao J, Baluarte HJ, Amaral S, Furth SL, Akimova T, Hancock WW, Levine MH, Reese PP, Beier UH.Transplant Direct. 2017 Jul 19;3(8):e199. doi: 10.1097/TXD.0000000000000715. eCollection 2017 Aug. PMID: 28795150.
Human lung tumor FOXP3+ Tregs upregulate four “Treg-locking” transcription factors. Akimova T, Zhang T, Negorev D, Singhal S, Stadanlick J, Rao A, Annunziata M, Levine MH, Beier UH, Diamond JM, Christie JD, Albelda SM, Eruslanov EB, Hancock WW. JCI Insight.
Histone/protein deacetylase 11 targeting promotes Foxp3+ Treg function. Huang J, Wang L, Dahiya S, Han R, Samanta A, Beier UH, Bhatti TR, Bergman J, Sotomayor EM, Seto E, Kozikowski AP, Hancock WW. Scientific Reports.
Utility of IL-2 complexes in promoting the survival of murine orthotopic forelimb vascularized composite allografts. Xu H, Dahiya S, Wang L, Akimova T, Han R, Zhang T, Zhang Y, Qin L, Levine MH, Hancock WW, Levin LS. Transplantation (In press)
Proximity Ligation Assay to Quantify Foxp3 Acetylation in Regulatory T Cells. Jiao J, Han R, Hancock WW, Beier UH. Methods in molecular biology (Clifton, N.J.). 2017; 1510:287-293.;
Models of Lung Transplant Research: a consensus statement from the National Heart, Lung, and Blood Institute workshop. Lama VN, Belperio JA, Christie JD, El-Chemaly S, Fishbein MC, Gelman AE, Hancock WW, Keshavjee S, Kreisel D, Laubach VE, Looney MR, McDyer JF, Mohanakumar T, Shilling RA, Panoskaltsis-Mortari A, Wilkes DS, Eu JP, Nicolls MR. JCI insight. 2017; 2(9).
Foxp3 Reprograms T Cell Metabolism to Function in Low-Glucose, High-Lactate Environments. Angelin A, Gil-de-Gómez L, Dahiya S, Jiao J, Guo L, Levine MH, Wang Z, Quinn WJ 3rd, Kopinski PK, Wang L, Akimova T, Liu Y, Bhatti TR, Han R, Laskin BL, Baur JA, Blair IA, Wallace DC, Hancock WW, Beier UH. Cell metabolism. 2017; 25(6):1282-1293.e7. NIHMSID: NIHMS839915.
Regulatory T cell signatures in liver transplant recipients successfully weaned from immunosuppression: Getting from here to there. Levine MH, Akimova T, Murken DR, Hancock WW. Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society. 2017; 23(7):875-877.
T cells lacking HDAC11 have increased effector functions and mediate enhanced alloreactivity in a murine model. Woods DM, Woan KV, Cheng F, Sodré AL, Wang D, Wu Y, Wang Z, Chen J, Powers J, Pinilla-Ibarz J, Yu Y, Zhang Y, Wu X, Zheng X, Weber J, Hancock WW, Seto E, Villagra A, Yu XZ, Sotomayor EM. Blood. 2017; 130(2):146-155.https://hancocklab.net/wp-admin/post.php?post=24&action=edit#save
2016
Standardization, Evaluation, and Area-Under-Curve Analysis of Human and Murine Treg Suppressive Function. Akimova T, Levine MH, Beier UH, Hancock WW. Methods in molecular biology (Clifton, N.J.). 2016; 1371:43-78.;
Targeting Sirtuin-1 prolongs murine renal allograft survival and function. Levine MH, Wang Z, Xiao H, Jiao J, Wang L, Bhatti TR, Hancock WW, Beier UH. Kidney international. 2016; 89(5):1016-26. NIHMSID: NIHMS759382;
Improved renal ischemia tolerance in females influences kidney transplantation outcomes. Aufhauser DD Jr, Wang Z, Murken DR, Bhatti TR, Wang Y, Ge G, Redfield RR 3rd, Abt PL, Wang L, Svoronos N, Thomasson A, Reese PP, Hancock WW, Levine MH. The Journal of clinical investigation. 2016; 126(5):1968-77.;
HDAC5 controls the functions of Foxp3(+) T-regulatory and CD8(+) T cells. Xiao H, Jiao J, Wang L, O’Brien S, Newick K, Wang LC, Falkensammer E, Liu Y, Han R, Kapoor V, Hansen FK, Kurz T, Hancock WW, Beier UH. International journal of cancer. 2016; 138(10):2477-86. NIHMSID: NIHMS869713;
Origin and Role of a Subset of Tumor-Associated Neutrophils with Antigen-Presenting Cell Features in Early-Stage Human Lung Cancer. Singhal S, Bhojnagarwala PS, O’Brien S, Moon EK, Garfall AL, Rao AS, Quatromoni JG, Stephen TL, Litzky L, Deshpande C, Feldman MD, Hancock WW, Conejo-Garcia JR, Albelda SM, Eruslanov EB. Cancer cell. 2016; 30(1):120-35. NIHMSID: NIHMS793568;
Isoform-Selective HDAC Inhibitor Therapy for Transplantation: Are We Ready for HDAC6? Hancock WW. Transplantation. 2016; 100(8):1597-8. NIHMSID: NIHMS766028;
Ubiquitin-specific Protease-7 Inhibition Impairs Tip60-dependent Foxp3+ T-regulatory Cell Function and Promotes Antitumor Immunity. Wang L, Kumar S, Dahiya S, Wang F, Wu J, Newick K, Han R, Samanta A, Beier UH, Akimova T, Bhatti TR, Nicholson B, Kodrasov MP, Agarwal S, Sterner DE, Gu W, Weinstock J, Butt TR, Albelda SM, Hancock WW. EBioMedicine. 2016; 13:99-112.;
2015
An optimized disaggregation method for human lung tumors that preserves the phenotype and function of the immune cells. Quatromoni JG, Singhal S, Bhojnagarwala P, Hancock WW, Albelda SM, Eruslanov E. Journal of leukocyte biology. 2015; 97(1):201-9.;
The inflammatory phenotype of the fibrous plate is distinct from the liver and correlates with clinical outcome in biliary atresia. Arva NC, Russo PA, Erlichman J, Hancock WW, Haber BA, Bhatti TR. Pathology, research and practice. 2015; 211(3):252-60.;
FOXP3+ regulatory T cell development and function require histone/protein deacetylase 3. Wang L, Liu Y, Han R, Beier UH, Bhatti TR, Akimova T, Greene MI, Hiebert SW, Hancock WW. The Journal of clinical investigation. 2015; 125(3):1111-23.;
Class-specific histone/protein deacetylase inhibition protects against renal ischemia reperfusion injury and fibrosis formation. Levine MH, Wang Z, Bhatti TR, Wang Y, Aufhauser DD, McNeal S, Liu Y, Cheraghlou S, Han R, Wang L, Hancock WW. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 2015; 15(4):965-73. NIHMSID: NIHMS861788;
Essential role of mitochondrial energy metabolism in Foxp3⁺ T-regulatory cell function and allograft survival. Beier UH, Angelin A, Akimova T, Wang L, Liu Y, Xiao H, Koike MA, Hancock SA, Bhatti TR, Han R, Jiao J, Veasey SC, Sims CA, Baur JA, Wallace DC, Hancock WW. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2015; 29(6):2315-26.;
FOXP3⁺ regulatory T cell development and function require histone/protein deacetylase 3. Wang L, Liu Y, Han R, Beier UH, Bhatti TR, Akimova T, Greene MI, Hiebert SW, Hancock WW. The Journal of clinical investigation. 2015; 125(8):3304.;
Pim-2 Kinase Influences Regulatory T Cell Function and Stability by Mediating Foxp3 Protein N-terminal Phosphorylation. Deng G, Nagai Y, Xiao Y, Li Z, Dai S, Ohtani T, Banham A, Li B, Wu SL, Hancock W, Samanta A, Zhang H, Greene MI. The Journal of biological chemistry. 2015; 290(33):20211-20.;
Thiol-Based Potent and Selective HDAC6 Inhibitors Promote Tubulin Acetylation and T-Regulatory Cell Suppressive Function. Segretti MC, Vallerini GP, Brochier C, Langley B, Wang L, Hancock WW, Kozikowski AP. ACS medicinal chemistry letters. 2015; 6(11):1156-61.;
